David P. Wolfer, MD Institute of Anatomy UZH and IBWS ETH Zurich

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Welcome! Information for Students, Fall Semester 2024 Lecture 'Vertiefung Neuroanatomie und Neurophysiologie' ETH 376-0007-01 - Moodle - content [ PDF ] - recommended reading 'Neuroanatomie' [ PDF ] - handouts 'Neuroanatomie' [ 1 PDF | 2 PDF | 3 PDF | 4 PDF ] Lecture 'Nervensystem', BSc Human Medicine ETH 377-0107-00 - Moodle - content [ PDF ] - recommended reading D.P. Wolfer [ PDF ] - handouts 'Hirnstamm und Hirnnerven' [ 25 PDF | 26 PDF | 27 PDF ] Current Research Our field of research is cognitive and behavioral neuroscience. My group uses mouse models to gain a better understanding of the role of the hippocampus in the control of behavior under normal and disease conditions. To this end we are also developing new approaches for automated high throughput analysis of behavior in the home cage. A further line of research investigates the effects of environment and exercise on hippocampal plasticity and cognitive function. Selected publications:[ Google Scholar | ResearcherID ] Brilkova M, Nigri M, Kumar HS, Moore J, Mantovani M, Keller C, Grimm A, Eckert A, Shcherbakov D, Akbergenov R, Seebeck P, Krämer SD, Wolfer DP, Gent TC, Böttger EC. Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice. Cell Rep 40:111433, 2022 Nigri M, Åhlgren J, Wolfer DP, Voikar V. Role of environment and experimenter in reproducibility of behavioral studies with laboratory mice. Front Behav Neurosci 16:e835444, 2022 Shcherbakov D, Nigri M, Akbergenov R, Brilkova M, Mantovani M, Petit PI, Grimm A, Karol AA, Teo Y, Sanchón AC, Kumar Y, Eckert A, Thiam K, Seebeck P, Wolfer DP, Böttger EC. Premature aging in mice with error-prone protein synthesis. Sci Adv 8:eabl9051, 2022 Luo W, Egger M, Domonkos A, Que L, Lukacsovich D, Cruz-Ochoa NA, Szocs S, Seng C, Arszovszki A, Sipos E, Amrein I, Winterer J, Lukacsovich T, Szabadics J, Wolfer DP, Varga C, Földy C. Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2. PNAS 118:e2108239118, 2021 Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Slazburger LR, Klein S, Han K, Weyer S, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC. Distinct in vivo role of APPsα versus APPsβ for spine density, synaptic plasticity and cognition. EMBO J 37:e98335, 2018 Voikar V, Krackow S, Lipp HP, Rau A, Colacicco G, Wolfer DP. Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage. Behav Brain Res 352:8-22, 2018 Hick M, Herrmann U, Weyer SW, Mallm P, Tschäpe J, Borgers M, Mercken M, Roth R, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC. Acute function of secreted Amyloid Precursor Protein fragment APPsα in synaptic plasticity. Acta Neuropathol 129:21-37, 2015